Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 10, Pages 692-702Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg3053
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Funding
- Max-Planck Society
- Ruder Boskovic Institute
- Zoological Institute of the Christian-Albrechts-University Kiel
- Unity Through Knowledge Fund [49]
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Gene evolution has long been thought to be primarily driven by duplication and rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes that lack homologues in other lineages and whose evolutionary origin is only poorly understood. Orphan genes might arise from duplication and rearrangement processes followed by fast divergence; however, de novo evolution out of non-coding genomic regions is emerging as an important additional mechanism. This process appears to provide raw material continuously for the evolution of new gene functions, which can become relevant for lineage-specific adaptations.
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