Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 7, Pages 459-463Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3001
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Funding
- Cancer Research UK
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RNA polymerase (Pol) III is highly specialized for the production of short non-coding RNAs. Once considered to be under relatively simple controls, recent studies using chromatin immunoprecipitation followed by sequencing (ChIP-seq) have revealed unexpected levels of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing overlap with Pol II transcription. Here I describe these novel insights and consider their implications and the questions that remain.
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