Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 1, Pages 21-35Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3094
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Funding
- European Research Council (ERC) [FP7/2007-2013]
- ERC [259043-CompBioMat]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- Swiss National Science Foundation [3100A0-112549]
- European Community
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Synthetic biology aims to create functional devices, systems and organisms with novel and useful functions on the basis of catalogued and standardized biological building blocks. Although they were initially constructed to elucidate the dynamics of simple processes, designed devices now contribute to the understanding of disease mechanisms, provide novel diagnostic tools, enable economic production of therapeutics and allow the design of novel strategies for the treatment of cancer, immune diseases and metabolic disorders, such as diabetes and gout, as well as a range of infectious diseases. In this Review, we cover the impact and potential of synthetic biology for biomedical applications.
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