Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 8, Pages 554-564Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3017
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Funding
- Human Frontier Science Program fellowship
- Marie Curie International Incoming Fellowship (IIF)
- European Molecular Biology Organisation (EMBO)
- Novartis Research Foundation
- European Union [LSHG-CT-2004-503433, LSHG-CT-2006-037415]
- European Research Council [ERC-204264, ERC-2010-StG 260481-MoBa-CS]
- SystemsX.ch
- Swiss initiative in Systems Biology
- Association of International Cancer Research [AICR10-0292]
- OncoSuisse [OCS-02365-02-2009]
- Swiss National Foundation [31003A_120205]
- Swiss National Science Foundation (SNF) [31003A-120205] Funding Source: Swiss National Science Foundation (SNF)
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In eukaryotes, all DNA-templated reactions occur in the context of chromatin. Nucleosome packaging inherently restricts DNA accessibility for regulatory proteins but also provides an opportunity to regulate DNA-based processes through modulating nucleosome positions and local chromatin structure. Recent advances in genome-scale methods are yielding increasingly detailed profiles of the genomic distribution of nucleosomes, their modifications and their modifiers. The picture now emerging is one in which the dynamic control of genome accessibility is governed by contributions from DNA sequence, ATP-dependent chromatin remodelling and nucleosome modifications. Here we discuss the interplay of these processes by reviewing our current understanding of how chromatin access contributes to the regulation of transcription, replication and repair.
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