Journal
NATURE REVIEWS GENETICS
Volume 13, Issue 1, Pages 7-13Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3080
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Funding
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Medical Research Council (MRC)
- EU Network of Excellence (NoE) EpiGeneSys
- EU SP BLUEPRINT
- Medical Research Council [G0801727] Funding Source: researchfish
- MRC [G0801727] Funding Source: UKRI
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Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
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