Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 5, Pages 357-362Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2983
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Funding
- Center of Translational Molecular Medicine (CTMM)
- European Commission
- InterUniversity Cardiology Institute Netherlands (ICIN)
- Netherlands Heart Foundation (NHS)
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Heart failure is an increasingly prevalent and highly lethal disease that is most often caused by underlying pathologies, such as myocardial infarction or hypertension, but it can also be the result of a single gene mutation. Comprehensive genetic and genomic approaches are starting to disentangle the diverse molecular underpinnings of both forms of the disease and promise to yield much-needed novel diagnostic and therapeutic options for specific subtypes of heart failure.
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