Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 1, Pages 32-42Publisher
NATURE RESEARCH
DOI: 10.1038/nrg2899
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Funding
- Wellcome Trust
- Burroughs Wellcome Fund
- David and Lucile Packard Foundation
- James S. McDonnell Foundation
- Alfred P. Sloan Foundation
- Defense Advanced Research Projects Agency [HR0011-05-1-0057]
- US National Institute of Allergy and Infectious Diseases [2U54AI057168]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI057168] Funding Source: NIH RePORTER
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Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.
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