Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 3, Pages 204-220Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2719
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Funding
- US National Institutes of Health National Research Service [US National Institutes of Health National Research Service Award 5F32GM820453]
- US National Institutes of Health [GM60398]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM060398, R01GM060398] Funding Source: NIH RePORTER
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Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological processes, including gene and transposon silencing, imprinting and X chromosome inactivation. Recent findings in plants and animals have greatly increased our understanding of the pathways used to accurately target, maintain and modify patterns of DNA methylation and have revealed unanticipated mechanistic similarities between these organisms. Key roles have emerged for small RNAs, proteins with domains that bind methylated DNA and DNA glycosylases in these processes. Drawing on insights from both plants and animals should deepen our understanding of the regulation and biological significance of DNA methylation.
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