Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 2, Pages 149-160Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2731
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Funding
- Wellcome Trust
- Medical Research Council
- Bill and Melinda Gates Foundation through the Foundation for the US National Institutes of Health
- MRC [G0600230, G19/9, G0600718] Funding Source: UKRI
- Medical Research Council [G0600718, G0600230, G19/9] Funding Source: researchfish
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Medical research in Africa has yet to benefit from the advent of genome-wide association (GWA) analysis, partly because the genotyping tools and statistical methods that have been developed for European and Asian populations struggle to deal with the high levels of genome diversity and population structure in Africa. However, the haplotypic diversity of African populations might help to overcome one of the major roadblocks in GWA research, the fine mapping of causal variants. We review the methodological challenges and consider how GWA studies in Africa will be transformed by new approaches in statistical imputation and large-scale genome sequencing.
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