Journal
NATURE REVIEWS GENETICS
Volume 12, Issue 1, Pages 19-31Publisher
NATURE RESEARCH
DOI: 10.1038/nrg2916
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Funding
- Boehringer Ingelheim Fonds
- National Institutes of Health
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062534] Funding Source: NIH RePORTER
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Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells. To perform their myriad roles, not only must precise small RNA species be generated, but they must also be loaded into specific effector complexes called RNA-induced silencing complexes (RISCs). Argonaute proteins form the core of RISCs and different members of this large family have specific expression patterns, protein binding partners and biochemical capabilities. In this Review, we explore the mechanisms that pair specific small RNA strands with their partner proteins, with an eye towards the substantial progress that has been recently made in understanding the sorting of the major small RNA classes - microRNAs (miRNAs) and small interfering RNAs (siRNAs) - in plants and animals.
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