Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 8, Pages 549-558Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2847
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Funding
- National Institute of General Medical Sciences [R01 GM55235]
- National Cancer Institute [R37 CA25417]
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The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with 'non-prototypical' subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.
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