Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 12, Pages 880-886Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2898
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Although genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in association studies. We propose that alternative approaches, which are largely borrowed from animal breeding, provide potential for advances. We review selected methods and discuss the challenges and opportunities ahead.
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