Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 10, Pages 673-684Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2830
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Funding
- NIGMS NIH HHS [R01 GM083337-03, R01 GM083337, P01 GM085354, P01 GM085354-020002] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM085354, R01GM083337] Funding Source: NIH RePORTER
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Mechanisms regulating where and when eukaryotic DNA replication initiates remain a mystery. Recently, genome-scale methods have been brought to bear on this problem. The identification of replication origins and their associated proteins in yeasts is a well-integrated investigative tool, but corresponding data sets from multicellular organisms are scarce. By contrast, standardized protocols for evaluating replication timing have generated informative data sets for most eukaryotic systems. Here, I summarize the genome-scale methods that are most frequently used to analyse replication in eukaryotes, the kinds of questions each method can address and the technical hurdles that must be overcome to gain a complete understanding of the nature of eukaryotic replication origins.
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