Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 1, Pages 32-42Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2485
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Funding
- National Institutes of Health
- D. W. Reynolds Clinical Cardiovascular Research Center
- Robert A. Welch Foundation
- Sandler Foundation for Asthma Research
- Deutsche Forschungsgemeinschaft [HA 3335/2-1]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL093039, R01HL083371] Funding Source: NIH RePORTER
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Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The expression of many HDAC isoforms in eukaryotic cells raises questions about their possible specificity or redundancy, and whether they control global or specific programmes of gene expression. Recent analyses of HDAC knockout mice have revealed highly specific functions of individual HDACs in development and disease. Mutant mice lacking individual HDACs are a powerful tool for defining the functions of HDACs in vivo and the molecular targets of HDAC inhibitors in disease.
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