Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 11, Pages 805-811Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2651
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Funding
- US National Institutes of Health [R37 CA082422, 5R01 CA083867, 5R01 CA124518]
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DNA methylation patterns are set up early in mammalian development and are then copied during the division of somatic cells. A long-established model for the maintenance of these patterns explains some, but not all, of the data that are now available. We propose a new model that suggests that the maintenance of DNA methylation relies not only on the recognition of hemimethylated DNA by DNA methyltransferase 1 (DNMT1) but also on the localization of the DNMT3A and DNMT3B enzymes to specific chromatin regions that contain methylated DNA.
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