Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 1, Pages 9-16Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2695
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Funding
- Israel Science Foundation Focal Initiatives in Research in Science and Technology (FIRST) [1615/09]
- Crown Human Genome Center
- Y. Leon Benoziyo Institute for Molecular Medicine
- M. D. Moross Institute for Cancer Research at the Weizmann Institute of Science
- Alon Fellowship
- Agence Nationale de la Recherche
- European Union [2005-018618]
- European Research Council
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Transcriptome-wide studies in eukaryotes have been instrumental in the characterization of fundamental regulatory mechanisms for more than a decade. By contrast, in prokaryotes (bacteria and archaea) whole-transcriptome studies have not been performed until recently owing to the general view that microbial gene structures are simple, as well as technical difficulties in enriching for mRNAs that lack poly(A) tails. Deep RNA sequencing and tiling array studies are now revolutionizing our understanding of the complexity, plasticity and regulation of microbial transcriptomes.
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