Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 11, Pages 745-755Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg2632
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Funding
- US National Institutes of Health [GM79558, DK56670]
- Searle Scholars Program
- US National Science Foundation [0733033]
- Direct For Biological Sciences [0733033] Funding Source: National Science Foundation
- Emerging Frontiers [0733033] Funding Source: National Science Foundation
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Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail. With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables. Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation. Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures.
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