Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 9, Pages 605-616Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2636
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Funding
- NCI NIH HHS [R01 CA045240-23, R01 CA045240] Funding Source: Medline
- NHGRI NIH HHS [U54 HG004558-03, U54 HG004558] Funding Source: Medline
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A crucial question in the field of gene regulation is whether the location at which a transcription factor binds influences its effectiveness or the mechanism by which it regulates transcription. Comprehensive transcription factor binding maps are needed to address these issues, and genome-wide mapping is now possible thanks to the technological advances of ChIP-chip and ChIP-seq. This Review discusses how recent genomic profiling of transcription factors gives insight into how binding specificity is achieved and what features of chromatin influence the ability of transcription factors to interact with the genome. It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions.
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