Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 12, Pages 872-878Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2670
Keywords
-
Categories
Funding
- UK Medical Research Council [G050079]
- Wellcome Trust [WT084728]
- US National Institute of Child Health and Human Development [HD44454]
- Medical Research Council/Economic and Social Research Council Interdisciplinary Fellowship [G0802681]
- Sir Henry Wellcome Fellowship [WT088984]
- Medical Research Council [G0500079, G9817803B, G19/2, G0802681] Funding Source: researchfish
- MRC [G19/2, G0500079, G0802681] Funding Source: UKRI
Ask authors/readers for more resources
After drifting apart for 100 years, the two worlds of genetics quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available