Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 1, Pages 31-46Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2626
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Funding
- National Human Genome Research Institute [R01 HG003573, R41 HG003072, R41 HG003265, R21 HG002443]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R21HG002443, R41HG003072, R01HG003573, U54HG003273, R41HG003265] Funding Source: NIH RePORTER
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Demand has never been greater for revolutionary technologies that deliver fast, inexpensive and accurate genome information. This challenge has catalysed the development of next-generation sequencing (NGS) technologies. The inexpensive production of large volumes of sequence data is the primary advantage over conventional methods. Here, I present a technical review of template preparation, sequencing and imaging, genome alignment and assembly approaches, and recent advances in current and near-term commercially available NGS instruments. I also outline the broad range of applications for NGS technologies, in addition to providing guidelines for platform selection to address biological questions of interest.
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