Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 4, Pages 233-240Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2523
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Funding
- National Institutes of Health (NIH) [DK-42910, DK-53839, DK-55342, R01GM085226]
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The forkhead box (Fox) family of transcription factors, which originated in unicellular eukaryotes, has expanded over time through multiple duplication events, and sometimes through gene loss, to over 40 members in mammals. Fox genes have evolved to acquire a specialized function in many key biological processes. Mutations in Fox genes have a profound effect on human disease, causing phenotypes as varied as cancer, glaucoma and language disorders. We summarize the salient features of the evolution of the Fox gene family and highlight the diverse contribution of various Fox subfamilies to developmental processes, from organogenesis to speech acquisition.
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