Journal
NATURE REVIEWS GENETICS
Volume 11, Issue 1, Pages 17-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2698
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Funding
- Human Frontier Science Program
- Institut Pasteur
- Centre National de la Recherche Scientifique
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche [ANR-08-MIEN-009-01]
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Pathogens have always been a major cause of human mortality, so they impose strong selective pressure on the human genome. Data from population genetic studies, including genome-wide scans for selection, are providing important insights into how natural selection has shaped immunity and host defence genes in specific human populations and in the human species as a whole. These findings are helping to delineate genes that are important for host defence and to increase our understanding of how past selection has had an impact on disease susceptibility in modern populations. A tighter integration between population genetic studies and immunological phenotype studies is now necessary to reveal the mechanisms that have been crucial for our past and present survival against infection.
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