Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 3, Pages 195-205Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg2526
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Funding
- Royal Society
- Natural Environment Research Council [NE/D00232X/1] Funding Source: researchfish
- NERC [NE/D00232X/1] Funding Source: UKRI
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The effective size of a population, N-e, determines the rate of change in the composition of a population caused by genetic drift, which is the random sampling of genetic variants in a finite population. N-e is crucial in determining the level of variability in a population, and the effectiveness of selection relative to drift. This article reviews the properties of N-e in a variety of different situations of biological interest, and the factors that influence it. In particular, the action of selection means that N-e varies across the genome, and advances in genomic techniques are giving new insights into how selection shapes N-e.
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