Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 9, Pages 617-627Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2633
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Funding
- Swiss National Science Foundation [31000-10767]
- National Heart, Lung and Blood Institute, the National Institutes of Health [N01-HV-28179]
- SystemsX.ch
- Swiss initiative for systems biology
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The systematic and quantitative molecular analysis of mutant organisms that has been pioneered by studies on mutant metabolomes and transcriptomes holds great promise for improving our understanding of how phenotypes emerge. Unfortunately, owing to the limitations of classical biochemical analysis, proteins have previously been excluded from such studies. Here we review how technical advances in mass spectrometry-based proteomics can be applied to measure changes in protein abundance, posttranslational modifications and protein-protein interactions in mutants at the scale of the proteome. We finally discuss examples that integrate proteomics data with genomic and phenomic information to build network-centred models, which provide a promising route for understanding how phenotypes emerge.
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