Journal
NATURE REVIEWS GENETICS
Volume 10, Issue 7, Pages 467-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2564
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Funding
- Medical Research Council [G0300723, G0800784] Funding Source: Medline
- Wellcome Trust [064421] Funding Source: Medline
- MRC [G0800784, G0300723] Funding Source: UKRI
- Medical Research Council [G0800784B, G0300723B] Funding Source: researchfish
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The preimplantation mammalian embryo offers a striking opportunity to address the question of how and why apparently identical cells take on separate fates. Two cell fate decisions are taken before the embryo implants; these decisions set apart a group of pluripotent cells, progenitors for the future body, from the distinct extraembryonic lineages of trophectoderm and primitive endoderm. New molecular, cellular and developmental insights reveal the interplay of transcriptional regulation, epigenetic modifications, cell position and cell polarity in these two fate decisions in the mouse. We discuss how mechanisms proposed in previously distinct models might work in concert to progressively reinforce cell fate decisions through feedback loops.
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