Journal
NATURE REVIEWS GENETICS
Volume 9, Issue 6, Pages 477-485Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2361
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01-GM40282, R01 GM040282] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM040282] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Linkage disequilibrium - the nonrandom association of alleles at different loci - is a sensitive indicator of the population genetic forces that structure a genome. Because of the explosive growth of methods for assessing genetic variation at a fine scale, evolutionary biologists and human geneticists are increasingly exploiting linkage disequilibrium in order to understand past evolutionary and demographic events, to map genes that are associated with quantitative characters and inherited diseases, and to understand the joint evolution of linked sets of genes. This article introduces linkage disequilibrium, reviews the population genetic processes that affect it and describes some of its uses. At present, linkage disequilibrium is used much more extensively in the study of humans than in non-humans, but that is changing as technological advances make extensive genomic studies feasible in other species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available