Journal
NATURE REVIEWS GENETICS
Volume 9, Issue 2, Pages 152-156Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2302
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Funding
- NHGRI NIH HHS [P50 HG003389-04, R01 HG004333, 5P50HG003389, P50 HG003389, R01HG004333] Funding Source: Medline
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The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.
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