Journal
NATURE REVIEWS GENETICS
Volume 9, Issue 4, Pages 291-302Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2335
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM071508, R01GM046406] Funding Source: NIH RePORTER
- NIGMS NIH HHS [P50 GM071508, R01 GM046406, R01 GM107466, GM-071508] Funding Source: Medline
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The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation ( amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.
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