Journal
NATURE REVIEWS GENETICS
Volume 9, Issue 10, Pages 749-763Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2428
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Funding
- the Howard Hughes Medical Institute (HHMI)
- the Mathers Foundation
- the Gordon and Virginia MacDonald Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM032373, R37GM032373, R01GM058815] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R37MH060233] Funding Source: NIH RePORTER
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What makes us human? Specialists in each discipline respond through the lens of their own expertise. In fact, 'anthropogeny' (explaining the origin of humans) requires a transdisciplinary approach that eschews such barriers. Here we take a genomic and genetic perspective towards molecular variation, explore systems analysis of gene expression and discuss an organ-systems approach. Rejecting any 'genes versus environment' dichotomy, we then consider genome interactions with environment, behaviour and culture, finally speculating that aspects of human uniqueness arose because of a primate evolutionary trend towards increasing and irreversible dependence on learned behaviours and culture perhaps relaxing allowable thresholds for large-scale genomic diversity.
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