Journal
NATURE REVIEWS GENETICS
Volume 9, Issue 5, Pages 341-355Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2346
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Funding
- NICHD NIH HHS [P50 HD055784] Funding Source: Medline
- NIMH NIH HHS [R37 MH060233-08, R37 MH060233, R01 MH064547, U54 MH068172, R01 MH64547, R37 MH60233, U54 MH68172] Funding Source: Medline
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Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.
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