Journal
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume 10, Issue 3, Pages 158-167Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrgastro.2013.10
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- MRC [G0300195] Funding Source: UKRI
- Medical Research Council [G0300195] Funding Source: researchfish
- Medical Research Council [G0300195] Funding Source: Medline
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In this Review, after a brief historical introduction, we first provide an overview of epidemiological studies that demonstrate an association between functional dyspepsia and psychological traits, states or psychiatric disorders. These studies suggest an important intrinsic role for psychosocial factors and psychiatric disorders, especially anxiety and depression, in the aetiopathogenesis of functional dyspepsia, in addition to their putative influence on health-care-seeking behaviour. Second, we describe pathophysiological evidence on how psychosocial factors and psychiatric disorders might exert their role in functional dyspepsia. Novel insights from functional brain imaging studies regarding the integration of gut brain signals, processed in homeostatic interoceptive brain regions, with input from the exteroceptive system, the reward system and affective and cognitive circuits, help to clarity the important role of psychological processes and psychiatric morbidity. We therefore propose an integrated model of functional dyspepsia as a disorder of gut brain signalling, supporting a biopsychosocial approach to the diagnosis and management of this disorder. Van Oudenhove, L. & Aziz, Q. Nat. Rev. Gastroenterol. Hepatol. 10,158-167 (2013); published online 29 January 2013; doi:10.1038/nrgastro.2013.10
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