Journal
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
Volume 10, Issue 4, Pages 245-255Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrgastro.2013.12
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Funding
- Enteric Vaccine Initiative-Program for Appropriate Technology in Health [U19 AI090873, U19 AI082655, U54 AI57168, R01 AI059223, R01 AI089519]
- Bill and Melinda Gates Foundation [38874, OPP1033572]
- Bill and Melinda Gates Foundation [OPP1033572] Funding Source: Bill and Melinda Gates Foundation
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Renewed awareness of the substantial morbidity and mortality that Shigella infection causes among young children in developing countries, combined with technological innovations in vaccinology, has led to the development of novel vaccine strategies in the past 5 years. Along with advancement of classic vaccines in clinical trials and new sophisticated measurements of immunological responses, much new data has been produced, lending promise to the potential for production of safe and effective Shigella vaccines. Herein, we review the latest progress in Shigella vaccine development within the framework of persistent obstacles. Barry, E. M. et al. Nat. Rev. Gastroenterol. Hepatol. 10, 245-255 (2013); published online 19 February 2013; doi:10.1038/nrgastro.2013.12
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