Journal
NATURE REVIEWS ENDOCRINOLOGY
Volume 8, Issue 12, Pages 743-754Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrendo.2012.189
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Funding
- National Institute of General Medical Sciences, NIH
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The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.
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