Related references
Note: Only part of the references are listed.Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
Rui-Hong Wang et al.
International Journal of Biological Sciences (2012)
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Lydia W. S. Finley et al.
CANCER CELL (2011)
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Peter Bai et al.
CELL METABOLISM (2011)
SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
Giorgio Ramadori et al.
CELL METABOLISM (2011)
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
Peter Bai et al.
CELL METABOLISM (2011)
Autophagy in the Cellular Energetic Balance
Rajat Singh et al.
CELL METABOLISM (2011)
Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction
William C. Hallows et al.
MOLECULAR CELL (2011)
The SirT3 Divining Rod Points to Oxidative Stress
Eric L. Bell et al.
MOLECULAR CELL (2011)
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
Mohan Viswanathan et al.
NATURE (2011)
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
Virginia Guarani et al.
NATURE (2011)
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
Sudarshana Purkayastha et al.
NATURE MEDICINE (2011)
Sirtuins, Aging, and Medicine
Leonard Guarente
NEW ENGLAND JOURNAL OF MEDICINE (2011)
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
E. L. Bell et al.
ONCOGENE (2011)
Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria
Huseyin Cimen et al.
BIOCHEMISTRY (2010)
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
Hyun-Seok Kim et al.
CANCER CELL (2010)
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Shinichi Someya et al.
CELL (2010)
被撤回的出版物: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (Retracted article. See vol. 158, pg. 959, 2014)
Gizem Donmez et al.
CELL (2010)
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
Lei Zhong et al.
CELL (2010)
Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?
Raffaele Teperino et al.
CELL METABOLISM (2010)
Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
Xiaolei Qiu et al.
CELL METABOLISM (2010)
SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production
Tadahiro Shimazu et al.
CELL METABOLISM (2010)
SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
Giorgio Ramadori et al.
CELL METABOLISM (2010)
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
Hyun-Seok Kim et al.
CELL METABOLISM (2010)
Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
Carles Canto et al.
CELL METABOLISM (2010)
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
Nirmala Hariharan et al.
CIRCULATION RESEARCH (2010)
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
Amy K. Walker et al.
GENES & DEVELOPMENT (2010)
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
Bhaskar Ponugoti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
Xiumei Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
Han Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
Michelle Pacholec et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition
Jiyoung Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
Carlos Escande et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
Shinji Kume et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
Akiko Satoh et al.
JOURNAL OF NEUROSCIENCE (2010)
Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
Thaddeus T. Schug et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress
Randa Tao et al.
MOLECULAR CELL (2010)
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
Raga Krishnakumar et al.
MOLECULAR CELL (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Amar J. Majmundar et al.
MOLECULAR CELL (2010)
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
Masato Iwabu et al.
NATURE (2010)
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey et al.
NATURE (2010)
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
Eric Verdin et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
Daniel Herranz et al.
NATURE COMMUNICATIONS (2010)
SIRT1: recent lessons from mouse models
Daniel Herranz et al.
NATURE REVIEWS CANCER (2010)
Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Michael Lefevre et al.
ATHEROSCLEROSIS (2009)
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
Takashi Nakagawa et al.
CELL (2009)
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Tiara L. A. Kawahara et al.
CELL (2009)
FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
Jongsook Kim Kemper et al.
CELL METABOLISM (2009)
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
Aparna Purushotham et al.
CELL METABOLISM (2009)
Oxygen Sensors at the Crossroad of Metabolism
Julian Aragones et al.
CELL METABOLISM (2009)
Regulation of Angiogenesis by Oxygen and Metabolism
Peter Fraisl et al.
DEVELOPMENTAL CELL (2009)
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
Dena E. Cohen et al.
GENES & DEVELOPMENT (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
Yongzhan Nie et al.
NATURE CELL BIOLOGY (2009)
Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
Isin Cakir et al.
PLOS ONE (2009)
JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
Nargis Nasrin et al.
PLOS ONE (2009)
Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
Yasukazu Nakahata et al.
SCIENCE (2009)
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD(+) Biosynthesis
Kathryn Moynihan Ramsey et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
Hidetaka Ota et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
Xiaoqing Zhang et al.
CELL (2008)
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
Yasukazu Nakahata et al.
CELL (2008)
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Gad Asher et al.
CELL (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
Alexander S. Banks et al.
CELL METABOLISM (2008)
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-induced Metabolic Disorders by Enhancing Fat Oxidation
Jerome N. Feige et al.
CELL METABOLISM (2008)
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
Olesya Vakhrusheva et al.
CIRCULATION RESEARCH (2008)
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
Marcella Fulco et al.
DEVELOPMENTAL CELL (2008)
Tissue-specific regulation of SIRT1 by calorie restriction
Danica Chen et al.
GENES & DEVELOPMENT (2008)
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1 - Possible role in AMP-activated protein kinase activation
Fan Lan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
Xiuyun Hou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Insulin sensitivity: modulation by nutrients and inflammation
Simon Schenk et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Substrates and regulation mechanisms for the human mitochondrial Sirtuins Sirt3 and Sirt5
Christine Schlicker et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Yi Liu et al.
NATURE (2008)
Negative regulation of the deacetylase SIRT1 by DBC1
Wenhui Zhao et al.
NATURE (2008)
DBC1 is a negative regulator of SIRT1
Ja-Eun Kim et al.
NATURE (2008)
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita et al.
NATURE (2008)
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
Timour Prozorovski et al.
NATURE CELL BIOLOGY (2008)
Phosphorylation Regulates SIRT1 Function
Tsutomu Sasaki et al.
PLOS ONE (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
miR-34a repression of SIRT1 regulates apoptosis
Munekazu Yamakuchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Sirt1 protects against high-fat diet-induced metabolic damage
Paul T. Pfluger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
Hong Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
David B. Lombard et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Laura Bordone et al.
AGING CELL (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
Eun-Joo Kim et al.
MOLECULAR CELL (2007)
SIRT1 controls endothelial angiogenic functions during vascular growth
Michael Potente et al.
GENES & DEVELOPMENT (2007)
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
Xiaoling Li et al.
MOLECULAR CELL (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
Hongying Yang et al.
CELL (2007)
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
Ilwola Mattagajasingh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase ero1-lα
Li Qiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
FXR: a promising target for the metabolic syndrome?
Bertrand Cariou et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α
Zachary Gerhart-Hines et al.
EMBO JOURNAL (2007)
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating α-tubulin
Wenbo Li et al.
JOURNAL OF NEUROSCIENCE (2007)
Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
Qinghong Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic β cells
Marcia C. Haigis et al.
CELL (2006)
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
William C. Hallows et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
Bjoern Schwer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
E Ford et al.
GENES & DEVELOPMENT (2006)
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
Ullas Kolthur-Seetharam et al.
CELL CYCLE (2006)
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
L Bordone et al.
PLOS BIOLOGY (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity
JB Pillai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Increase in activity during calorie restriction requires Sirt1
D Chen et al.
SCIENCE (2005)
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
WY Chen et al.
CELL (2005)
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
F Berger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
SH Koo et al.
NATURE (2005)
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
E Nisoli et al.
SCIENCE (2005)
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
YI Kitamura et al.
CELL METABOLISM (2005)
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
KA Moynihan et al.
CELL METABOLISM (2005)
Endothelial aging
RP Brandes et al.
CARDIOVASCULAR RESEARCH (2005)
Substrate-specific activation of sirtuins by resveratrol
M Kaeberlein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Calorie restriction -: the SIR2 connection
L Guarente et al.
CELL (2005)
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet et al.
SCIENCE (2004)
The role of autophagy during the early neonatal starvation period
A Kuma et al.
NATURE (2004)
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
S Nemoto et al.
SCIENCE (2004)
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
JR Revollo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
H Daitoku et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
B Rogina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Autophagy in health and disease: A double-edged sword
T Shintani et al.
SCIENCE (2004)
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
F Picard et al.
NATURE (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
HL Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
P Puigserver et al.
NATURE (2003)
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
SC Dryden et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
The mammalian SIR2 alpha protein has a role in embryogenesis and gametogenesis
MW McBurney et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
HH Zong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
JL Avalos et al.
MOLECULAR CELL (2002)
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
T Yamauchi et al.
NATURE MEDICINE (2001)
Structure of the histone deacetylase SIRT2
MS Finnin et al.
NATURE STRUCTURAL BIOLOGY (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)
Role of NAD+ in the deacetylase activity of the SIR2-like proteins
J Landry et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)