Journal
NATURE REVIEWS ENDOCRINOLOGY
Volume 8, Issue 10, Pages 572-573Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrendo.2012.143
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Acromegaly is caused by a growth-hormone-secreting pituitary adenoma. Mutations in the AIP gene predispose patients to young-onset pituitary adenomas that are resistant to somatostatin analogue therapy. Chalal et al. describe a potential mechanism by which AIP modulates responsiveness to somatostatin analogues and identify PLAGL1 as a potential modulator of therapeutic activity.
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