4.6 Review

Lipodystrophy: pathophysiology and advances in treatment

Related references

Note: Only part of the references are listed.
Review Medicine, General & Internal

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

Theodore Kelesidis et al.

ANNALS OF INTERNAL MEDICINE (2010)

Review Biochemistry & Molecular Biology

Drug-induced lipotoxicity: Lipodystrophy associated with HIV-1 infection and antiretroviral treatment

Francesc Villarroya et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

Editorial Material Endocrinology & Metabolism

Leptin therapy in lipodystrophy

D. B. Savage et al.

DIABETOLOGIA (2010)

Article Endocrinology & Metabolism

Efficacy of leptin therapy in the different forms of human lipodystrophy

A. Y. Chong et al.

DIABETOLOGIA (2010)

Review Endocrinology & Metabolism

RATIONALE FOR LEPTIN-REPLACEMENT THERAPY FOR SEVERE LIPODYSTROPHY

Elif A. Oral et al.

ENDOCRINE PRACTICE (2010)

Article Endocrinology & Metabolism

Resistance to leptin-replacement therapy in Berardinelli-Seip congenital lipodystrophy: an immunological origin

Jacques Beltrand et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2010)

Article Gastroenterology & Hepatology

Inhibition of Mitochondrial Function by Efavirenz Increases Lipid Content in Hepatic Cells

Ana Blas-Garcia et al.

HEPATOLOGY (2010)

Article Infectious Diseases

A Meta-Analysis of Six Placebo-Controlled Trials of Thiazolidinedione Therapy for HIV Lipoatrophy

Janet M. Raboud et al.

HIV CLINICAL TRIALS (2010)

Article Public, Environmental & Occupational Health

Assessment of Ultrasound for Use in Detecting Lipoatrophy in HIV-Infected Patients Taking Combination Antiretroviral Therapy

Klaudija Viskovic et al.

AIDS PATIENT CARE AND STDS (2009)

Review Biochemistry & Molecular Biology

Lipodystrophies: Disorders of adipose tissue biology

Abhimanyu Garg et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

Article Medicine, Research & Experimental

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC

Oscar Rubio-Cabezas et al.

EMBO MOLECULAR MEDICINE (2009)

Review Pharmacology & Pharmacy

Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report

Jianyong Wu et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2009)

Article Medicine, Research & Experimental

HIV-1 Protease Inhibitor Induced Oxidative Stress Suppresses Glucose Stimulated Insulin Release: Protection with Thymoquinone

Surabhi Chandra et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

Article Immunology

The Effect of Individual Antiretroviral Drugs on Body Composition in HIV-Infected Persons Initiating Highly Active Antiretroviral Therapy

Judith C. Shlay et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2009)

Editorial Material Endocrinology & Metabolism

Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome?

Christos S. Mantzoros

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Medicine, Research & Experimental

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

Yukiko K. Hayashi et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Medicine, Research & Experimental

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

Isabelle Mercier et al.

LABORATORY INVESTIGATION (2009)

Article Gastroenterology & Hepatology

Hepatitis C, human immunodeficiency virus and metabolic syndrome: interactions

Donald P. Kotler

LIVER INTERNATIONAL (2009)

Article Endocrinology & Metabolism

GH/GHRH axis in HIV lipodystrophy

Takara L. Stanley et al.

PITUITARY (2009)

Review Infectious Diseases

Long term adverse effects related to nucleoside reverse transcriptase inhibitors: Clinical impact of mitochondrial toxicity

Anne Maagaard et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2009)

Article Immunology

Genetic analysis implicates resistin in HIV lipodystrophy

Koustubh Ranade et al.

Article Public, Environmental & Occupational Health

Metformin Increases HDL3-Cholesterol and Decreases Subcutaneous Truncal Fat in Nondiabetic Patients with HIV-Associated Lipodystrophy

Leandro A. Diehl et al.

AIDS PATIENT CARE AND STDS (2008)

Article Genetics & Heredity

Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability

Vinaya Simha et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2008)

Article Endocrinology & Metabolism

Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy

Ksenia Sevastianova et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Article Endocrinology & Metabolism

Leptin therapy for partial lipodystrophy linked to a PPAR-γ mutation

[Anonymous]

CLINICAL ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

The human lipodystrophy gene BSCL2/Seipin may be essential for normal adipocyte differentiation

Victoria A. Payne et al.

DIABETES (2008)

Article Biochemistry & Molecular Biology

AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus

Andressa Coope et al.

FEBS LETTERS (2008)

Article Medicine, General & Internal

Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation - A randomized controlled trial

Janet Lo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)

Review Infectious Diseases

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

Jane E. Mallewa et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)

Review Endocrinology & Metabolism

Approach to the human immunodeficiency virus-infected patient with lipodystrophy

Todd T. Brown

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Endocrinology & Metabolism

Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy

M. C. Vantyghem et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Endocrinology & Metabolism

Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy

C. A. Kim et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Article Biochemistry & Molecular Biology

Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia

Henian Cao et al.

LIPIDS IN HEALTH AND DISEASE (2008)

Article Pediatrics

Acquired partial lipodystrophy in an 11-year-old girl

Joanna Oswiecimska et al.

PEDIATRICS INTERNATIONAL (2008)

Article Medicine, General & Internal

Metabolic effects of a growth hormone-releasing factor in patients with HIV

Julian Falutz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Endocrinology & Metabolism

Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report

F. Moreau et al.

DIABETES & METABOLISM (2007)

Article Biochemistry & Molecular Biology

Lipids in health and disease

Kevin W. Johns et al.

LIPIDS IN HEALTH AND DISEASE (2007)

Article Medicine, General & Internal

Tumour necrosis factor-α in human adipose tissue -: from signalling mechanisms to clinical implications

M. Ryden et al.

JOURNAL OF INTERNAL MEDICINE (2007)

Article Immunology

A randomized, placebo-controlled trial of rosiglitazone for HIV-related lipoatrophy

Rodrigo B. Cavalcanti et al.

JOURNAL OF INFECTIOUS DISEASES (2007)

Article Medicine, General & Internal

Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes

Steven E. Nissen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Review Immunology

The role of adipokines in relation to HIV lipodystrophy

Laura L. Sweeney et al.

Review Gastroenterology & Hepatology

Obesity, inflammation, and insulin resistance

Steven E. Shoelson et al.

GASTROENTEROLOGY (2007)

Article Endocrinology & Metabolism

Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy

Jean Y. Park et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2007)

Article Environmental Sciences

Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to zidovudine

Rao L. Divi et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2007)

Article Medicine, Research & Experimental

Hypotension, lipodystrophy, and insulin resistance in generalized PPARγ-deficient mice rescued from embryonic lethality

Sheng Zhong Duan et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Clinical Neurology

Muscle and nerve pathology in Dunnigan familial partial lipodystrophy

S. Spuler et al.

NEUROLOGY (2007)

Article Endocrinology & Metabolism

Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy

Ken Ebihara et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

Article Medicine, General & Internal

Effectiveness of subcutaneous growth hormone in HIV-1 patients with moderate to severe facial lipoatrophy

Miwako Honda et al.

INTERNAL MEDICINE (2007)

Article Endocrinology & Metabolism

Thiazolidinedione treatment decreases bone mineral density in type 2 diabetic men

Subhashini Yaturu et al.

DIABETES CARE (2007)

Article Dermatology

Childhood acquired lipodystrophy: A retrospective study

Elena Pope et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2006)

Article Endocrinology & Metabolism

Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia

Colleen Hadigan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Genetics & Heredity

Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy

Robert A. Hegele et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Sport Sciences

Exercise training in HIV-1-infected individuals with dyslipidemia and lipodystrophy

L Terry et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2006)

Article Biochemistry & Molecular Biology

Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy

RL Boguslavsky et al.

HUMAN MOLECULAR GENETICS (2006)

Article Health Policy & Services

Strategies for management and treatment of dyslipidemia in HIV/AIDS

PE Sax

AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV (2006)

Article Endocrinology & Metabolism

Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy

EA Oral et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Medicine, General & Internal

Comparison of rosiglitazone and metformin for treating HIV lipodystrophy - A randomized trial

JPH van Wijk et al.

ANNALS OF INTERNAL MEDICINE (2005)

Article Infectious Diseases

Impact of rosiglitazone treatment on the bioavailability of antiretroviral compounds in HIV-positive patients

M Oette et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)

Article Endocrinology & Metabolism

Long-term efficacy of leptin replacement in patients with generalized lipodystrophy

ED Javor et al.

DIABETES (2005)

Article Gastroenterology & Hepatology

Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy

ED Javor et al.

HEPATOLOGY (2005)

Article Medicine, General & Internal

Medical progress - Cardiovascular risk and body-fat abnormalities in HIV-infected adults.

S Grinspoon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Endocrinology & Metabolism

Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy

SA Moran et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2004)

Review Infectious Diseases

HIV infection, HAART, and endothelial adhesion molecules: current perspectives

KD Donati et al.

LANCET INFECTIOUS DISEASES (2004)

Review Medicine, General & Internal

Medical progress - Acquired and inherited lipodystrophies

A Garg

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Medicine, Research & Experimental

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

E Asilmaz et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Endocrinology & Metabolism

Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy

JA Johnson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Article Endocrinology & Metabolism

Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency

JR McDuffie et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Article Medicine, General & Internal

Low-dose growth hormone and human immunodeficiency virus-associated lipodystrophy syndrome: a pilot study

O Andersen et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2004)

Review Neurosciences

Adiponectin: Novelties in metabolism and hormonal regulation

LH Duntas et al.

NUTRITIONAL NEUROSCIENCE (2004)

Article Medicine, General & Internal

Growth hormone-releasing hormone in HIV-infected men with lipodystrophy - A randomized controlled trial

P Koutkia et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

Article Endocrinology & Metabolism

Leptin hormonal kinetics in the fed state: Effects of adiposity, age, and gender on endogenous leptin production and clearance rates

SL Wong et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Article Medicine, General & Internal

Fenofibrate is effective in treating hypertriglyceridemia associated with HIV lipodystrophy

A Rao et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2004)

Review Endocrinology & Metabolism

Lipodystrophies: rare disorders causing metabolic syndrome

A Garg et al.

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2004)

Article Multidisciplinary Sciences

A family with severe insulin resistance and diabetes due to a mutation in AKT2

S George et al.

SCIENCE (2004)

Article Medicine, General & Internal

Metabolic effects of rosiglitazone in HIV lipodystrophy - A randomized, controlled trial

C Hadigan et al.

ANNALS OF INTERNAL MEDICINE (2004)

Article Biochemistry & Molecular Biology

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

AK Agarwal et al.

HUMAN MOLECULAR GENETICS (2003)

Article Endocrinology & Metabolism

Kobberling type of familial partial lipodystrophy - An underrecognized syndrome

KL Herbst et al.

DIABETES CARE (2003)

Article Endocrinology & Metabolism

Regulation of adiponectin in human immunodeficiency virus-infected patients:: Relationship to body composition and metabolic indices

Q Tong et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)

Article Immunology

Adiponectin and leptin levels in HIV-Infected subjects with insulin resistance and body fat redistribution

DC Mynarcik et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2002)

Article Immunology

Improved insulin sensitivity and body fat distribution in HIV-infected patients treated with rosiglitazone: A pilot study

MC Gelato et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2002)

Article Endocrinology & Metabolism

Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy

C Hadigan et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2002)

Article Endocrinology & Metabolism

Measuring body fat distribution and content in humans

BH Goodpaster

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2002)

Article Genetics & Heredity

Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C

G Novelli et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2002)

Article Endocrinology & Metabolism

Serum adiponectin and leptin levels in patients with lipodystrophies

WA Haque et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Article Genetics & Heredity

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34

AK Agarwal et al.

NATURE GENETICS (2002)

Article Medicine, General & Internal

Leptin-replacement therapy for lipodystrophy

EA Oral et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Endocrinology & Metabolism

A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy

AK Agarwal et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Article Medicine, General & Internal

Metformin in the treatment of HIV lipodystrophy syndrome - A randomized controlled trial

C Hadigan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)

Article Biochemistry & Molecular Biology

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

JK Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Endocrinology & Metabolism

Gender differences in the prevalence of metabolic complications in familial partial lipodystrophy (Dunnigan variety)

A Garg

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)

Article Medicine, Research & Experimental

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

O Gavrilova et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Biochemistry & Molecular Biology

Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy

H Cao et al.

HUMAN MOLECULAR GENETICS (2000)