4.6 Review

Effects of poor and short sleep on glucose metabolism and obesity risk

Journal

NATURE REVIEWS ENDOCRINOLOGY
Volume 5, Issue 5, Pages 253-261

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nrendo.2009.23

Keywords

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Funding

  1. US National Institute of Health [P01 AG-11412, R01 HL-075079, P60 DK-20595, R01 DK-0716960, R01 HL-075025, M01 RR000055]
  2. US Department of Defense [W81XWH-07-2-0071]
  3. AASM/Pfizer
  4. Belgian 'Fonds de la Recherche Scientifique Medicale' [FRSM-3.4583.02]
  5. 'Fonds National de la Recherche Scientifique' (FNRS)
  6. 'CARE Foundation'
  7. INSERM [U628]
  8. Claude Bernard University of Lyon, France
  9. NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000055] Funding Source: NIH RePORTER
  10. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL075025, R01HL075079] Funding Source: NIH RePORTER
  11. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071696, P60DK020595] Funding Source: NIH RePORTER
  12. NATIONAL INSTITUTE ON AGING [P01AG011412] Funding Source: NIH RePORTER

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The importance of sleep to hormones and glucose metabolism was first documented more than four decades ago. since then, sleep curtailment has become an endemic behavior in modern society. in addition, the prevalence of sleep disorders, particularly obstructive sleep apnea (OsA), has increased. OsA is very common in endocrine and metabolic disorders, but often remains undiagnosed. This review summarizes the laboratory and epidemiologic evidence that suggests how sleep loss, either behavioral or disease-related, and poor quality of sleep might promote the development of obesity and diabetes mellitus, and exacerbate existing endocrine conditions. Treatment of sleep disorders has the potential to improve glucose metabolism and energy balance. screening for habitual sleep patterns and OsA might be critically important for patients with endocrine and metabolic disorders.

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