Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 7, Pages 513-532Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd4233
Keywords
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Funding
- USC Norris Comprehensive Cancer Center [P30 CA014089]
- US National Institutes of Health (NIH) [1R01CA166161-01A1, 1R21NS074392-01, 1R21AI105057-01, NIH 1R01 HL112638-01]
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WNT-beta-catenin signalling is involved in a multitude of developmental processes and the maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation, migration, genetic stability and apoptosis, as well as by maintaining adult stem cells in a pluripotent state. Not surprisingly, aberrant regulation of this pathway is therefore associated with a variety of diseases, including cancer, fibrosis and neurodegeneration. Despite this knowledge, therapeutic agents specifically targeting the WNT pathway have only recently entered clinical trials and none has yet been approved. This Review examines the problems and potential solutions to this vexing situation and attempts to bring them into perspective.
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