Related references
Note: Only part of the references are listed.PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients
Peter Molenaar et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production
Issaka Yougbare et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2013)
The Future of Peptide-based Drugs
David J. Craik et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2013)
Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart
Sanja Beca et al.
CIRCULATION RESEARCH (2013)
Novel Anti-Inflammatory Agents in COPD: Targeting Lung and Systemic Inflammation
Stelios Loukides et al.
CURRENT DRUG TARGETS (2013)
A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
Emilia Guirguis et al.
ENDOCRINOLOGY (2013)
Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1
David G. Parkes et al.
EXPERT OPINION ON DRUG DISCOVERY (2013)
Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease
Louisa C. Y. Lee et al.
FUTURE MEDICINAL CHEMISTRY (2013)
Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease
Peter J. Barnes
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)
Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury
Masayoshi Oikawa et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)
Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF
S. S. Pullamsetti et al.
ONCOGENE (2013)
Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers
De-Chen Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Phosphodiesterase-8A binds to and regulates Raf-1 kinase
Kim M. Brown et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Effect of the Mixed Phosphodiesterase 3/4 Inhibitor RPL554 on Human Isolated Bronchial Smooth Muscle Tone
Luigino Calzetta et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Phosphodiesterase 4 Inhibition in the Treatment of Psoriasis, Psoriatic Arthritis and Other Chronic Inflammatory Diseases
Miriam Wittmann et al.
DERMATOLOGY AND THERAPY (2013)
Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary Disease
Debra J. Reid et al.
ANNALS OF PHARMACOTHERAPY (2012)
Structure and Regulation of Soluble Guanylate Cyclase
Emily R. Derbyshire et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)
Effect of cilostazol on the progression of carotid intima-media thickness: A meta-analysis of randomized controlled trials
Deng-feng Geng et al.
ATHEROSCLEROSIS (2012)
Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D
Zhaoxia Huo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function
Alessandra Stangherlin et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia
Neil S. Cutshall et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Discovery of oxazole-based PDE4 inhibitors with picomolar potency
Rongze Kuang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors
Udo Bauer et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux
Robert M. Rzasa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia
Ginny D. Ho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model
Abhisek Banerjee et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
Therese Keravis et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Cilostazol-Based Triple Antiplatelet Therapy Compared to Dual Antiplatelet Therapy in Patients with Coronary Stent Implantation: A Meta-Analysis of 5,821 Patients
Deng-feng Geng et al.
CARDIOLOGY (2012)
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Sung-Jun Park et al.
CELL (2012)
Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468
R. Saravani et al.
CELL PROLIFERATION (2012)
Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling
Manling Zhang et al.
CIRCULATION (2012)
Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A-Mediated Regulation of Distinct Phosphodiesterases
Alessandra Ghigo et al.
CIRCULATION (2012)
Nitrates as an Integral Part of Optimal Medical Therapy and Cardiac Rehabilitation for Stable Angina: Review of Current Concepts and Therapeutics
William E. Boden et al.
CLINICAL CARDIOLOGY (2012)
Identification of novel genetic variants in phosphodiesterase 8B ( PDE8B ), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours
Anya Rothenbuhler et al.
CLINICAL ENDOCRINOLOGY (2012)
New bronchodilators
Garbo Mak et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Selective PDE inhibitors as novel treatments for respiratory diseases
Clive P. Page et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Tetomilast: new promise for phosphodiesterase-4 inhibitors?
Stephen J. Bickston et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)
PDE Inhibition and cognition enhancement
Arjan Blokland et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay
L. -C. L. Tsai et al.
GENES BRAIN AND BEHAVIOR (2012)
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome
Anna Terrin et al.
JOURNAL OF CELL BIOLOGY (2012)
Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus
E. F. M. Wouters et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer
Essa Hu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors
Michelle M. Claffey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design
Fei Meng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
AKAPs: The architectural underpinnings of local cAMP signaling
Michael D. Kritzer et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)
The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice
Shervin Liddie et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2012)
The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease A Systematic Review
Jannet A. Eindhoven et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)
Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias
Cristina E. Molina et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)
Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction
Jun Kotera et al.
JOURNAL OF UROLOGY (2012)
Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells
Daisuke Yamanaka et al.
MOLECULAR ENDOCRINOLOGY (2012)
Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig
W. B. Johnson et al.
LIFE SCIENCES (2012)
Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor
Therese Keravis et al.
PLOS ONE (2012)
Inhaled corticosteroid and long-acting β2-agonist pharmacological profiles: effective asthma therapy in practice
Michael Tamm et al.
RESPIRATORY MEDICINE (2012)
Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway
Takekatsu Saito et al.
SCIENTIFIC WORLD JOURNAL (2012)
Resveratrol as a calorie restriction mimetic: therapeutic implications
Jay H. Chung et al.
TRENDS IN CELL BIOLOGY (2012)
Protein Kinase G Iα Inhibits Pressure Overload-Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo
Robert M. Blanton et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2012)
cAMP-Specific Phosphodiesterases 8A and 8B, Essential Regulators of Leydig Cell Steroidogenesis
Masami Shimizu-Albergine et al.
MOLECULAR PHARMACOLOGY (2012)
Cilostazol Suppresses Angiotensin II-Induced Vasoconstriction via Protein Kinase A-Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel
Kinue Nishioka et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells
Yujun Cai et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
Clint L. Miller et al.
BASIC RESEARCH IN CARDIOLOGY (2011)
Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
Klaus F. Rabe
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Sildenafil Reverses ABCB1-and ABCG2-Mediated Chemotherapeutic Drug Resistance
Zhi Shi et al.
CANCER RESEARCH (2011)
Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer
Zhi Shi et al.
CANCER RESEARCH (2011)
cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes
Alessandra Stangherlin et al.
CIRCULATION RESEARCH (2011)
Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current
Sanja Beca et al.
CIRCULATION RESEARCH (2011)
PDE inhibitors: a new approach to treat metabolic syndrome?
Claire Lugnier
CURRENT OPINION IN PHARMACOLOGY (2011)
Subcellular signaling in the endothelium: cyclic nucleotides take their place
Donald H. Maurice
CURRENT OPINION IN PHARMACOLOGY (2011)
The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis
Li-Chun Lisa Tsai et al.
CURRENT OPINION IN PHARMACOLOGY (2011)
PDE1 isozymes, key regulators of pathological vascular remodeling
Stefan Chan et al.
CURRENT OPINION IN PHARMACOLOGY (2011)
PDE5 inhibitors: targeting erectile dysfunction in diabetics
Sharron H. Francis et al.
CURRENT OPINION IN PHARMACOLOGY (2011)
PDE3 inhibition in dilated cardiomyopathy
Matthew Movsesian et al.
CURRENT OPINION IN PHARMACOLOGY (2011)
Phosphodiesterases and regulation of female reproductive function
Marco Conti
CURRENT OPINION IN PHARMACOLOGY (2011)
Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment
Isaac Levy et al.
CURRENT OPINION IN PHARMACOLOGY (2011)
PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia
Jan Kehler et al.
CURRENT PHARMACEUTICAL DESIGN (2011)
Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia
Lingzhi Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
Frank Christian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Biochemical Basis of Asthma Therapy
Peter J. Barnes
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Plasma Membrane Calcium Pump (PMCA4)-Neuronal Nitric-oxide Synthase Complex Regulates Cardiac Contractility through Modulation of a Compartmentalized Cyclic Nucleotide Microdomain
Tamer M. A. Mohamed et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Phosphodiesterase 2A Isoform Localized to Mitochondria Regulates Respiration
Rebeca Acin-Perez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells
Lindsay S. Wilson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins
Najma Begum et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Effects of cilostazol in the heart
Natnicha Kanlop et al.
JOURNAL OF CARDIOVASCULAR MEDICINE (2011)
Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused by PRKAR1A Mutations: PDE11A May Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype
Rossella Libe et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
Jerome Leroy et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia
Christopher J. Helal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors
Michael S. Malamas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes
Y. Y. Sin et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)
Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington's Disease
Robin J. Kleiman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization
Cathy J. Tralau-Stewart et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Are Phosphodiesterase Type 5 Inhibitors Associated with Vision-Threatening Adverse Events? A Critical Analysis and Review of the Literature
Faris Azzouni et al.
JOURNAL OF SEXUAL MEDICINE (2011)
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Madson Q. Almeida et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)
Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ
Alessia Perino et al.
MOLECULAR CELL (2011)
Intra-Cellular Therapies and Takeda to develop PDE1 inhibitors for schizophrenia
[Anonymous]
NATURE REVIEWS DRUG DISCOVERY (2011)
Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients
Malgorzata Labuda et al.
MEDIATORS OF INFLAMMATION (2011)
Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution
Elisabeth Piccart et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2011)
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
P. H. Hutson et al.
NEUROPHARMACOLOGY (2011)
Tadalafil for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: Pathophysiology and Mechanism(s) of Action
Karl-Erik Andersson et al.
NEUROUROLOGY AND URODYNAMICS (2011)
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Sharron H. Francis et al.
PHYSIOLOGICAL REVIEWS (2011)
Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling
Xia Tian et al.
PLOS ONE (2011)
Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
Lincoln R. Potter
PHARMACOLOGY & THERAPEUTICS (2011)
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
Yun-Hee Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease
Yasuo To et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways
Frank Christian et al.
CELLULAR SIGNALLING (2010)
The Phosphodiesterase Inhibitor Cilostazol Induces Regression of Carotid Atherosclerosis in Subjects With Type 2 Diabetes Mellitus Principal Results of the Diabetic Atherosclerosis Prevention by Cilostazol (DAPC) Study: A Randomized Trial
Naoto Katakami et al.
CIRCULATION (2010)
Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes
Liliana R. V. Castro et al.
CIRCULATION RESEARCH (2010)
A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity
Bryan Serrels et al.
CURRENT BIOLOGY (2010)
Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs
Therese Keravis et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex
Michelle L. Halls et al.
EMBO JOURNAL (2010)
Targeting cancer with phosphodiesterase inhibitors
Rajkumar Savai et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma
S. -L. Catherine Jin et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)
Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain
Huanchen Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability
Sarah N. Rampersad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
cAMP-stimulated Protein Phosphatase 2A Activity Associated with Muscle A Kinase-anchoring Protein (mAKAP) Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-specific Phosphodiesterase PDE4D3
Kimberly L. Dodge-Kafka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors
Norbert Hoefgen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes
Enrico Patrucco et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D
Hyun Wook Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains
Himabindu Penmatsa et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
Alex B. Burgin et al.
NATURE BIOTECHNOLOGY (2010)
Putting the lid on phosphodiesterase 4
Miles D. Houslay et al.
NATURE BIOTECHNOLOGY (2010)
Signal integration through blending, bolstering and bifurcating of intracellular information
Catherine T. Pawson et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease
Carmela Giampa et al.
PLOS ONE (2010)
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes
Michele P. Kelly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy
Candace M. Adamo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats
Yu-Fang Cheng et al.
PSYCHOPHARMACOLOGY (2010)
The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
Dave Singh et al.
RESPIRATORY RESEARCH (2010)
Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes
Daniel R. Raymond et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
Michael Kranz et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
A new therapeutic approach in Parkinson's disease: Some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents
Sachin S. Laddha et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
Michael P. DeNinno et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease
Katharine H. Banner et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Role of Ca2+/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
Clint L. Miller et al.
CIRCULATION RESEARCH (2009)
Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B
Ren Zhang et al.
ENDOCRINOLOGY (2009)
ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes
Kumiko Kadoshima-Yamaoka et al.
IMMUNOLOGY LETTERS (2009)
Dual Acylation of PDE2A Splice Variant 3 TARGETING TO SYNAPTIC MEMBRANES
Corina Russwurm et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Differential Association of Phosphodiesterase 4D Isoforms with β2-Adrenoceptor in Cardiac Myocytes
Vania De Arcangelis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3
Cecile Terrenoire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia
Patrick R. Verhoest et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor
Hon-Wah Man et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
Steven M. Grauer et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
Leonardo M. Fabbri et al.
LANCET (2009)
Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons
Katherine D. Cygnar et al.
NATURE NEUROSCIENCE (2009)
Capturing adenylyl cyclases as potential drug targets
Sandra Pierre et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Phosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension.
Stephen L. Archer et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity
Ermanno Puxeddu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
Jayvardhan Pandit et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
Olga A. H. Reneerkens et al.
PSYCHOPHARMACOLOGY (2009)
Efficacy of Cilostazol in reducing restenosis in patients undergoing contemporary stent based PCI: a meta-analysis of randomised controlled trials
Umesh Tamhane et al.
EUROINTERVENTION (2009)
Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals
Michele P. Kelly et al.
GENETIC MODELS OF SCHIZOPHRENIA (2009)
DISC1, PDE4B, and NDE1 at the centrosome and synapse
Nicholas J. Bradshaw et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model
Keith L. Black et al.
BRAIN RESEARCH (2008)
Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets
H. A. Toque et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
Wito Richter et al.
EMBO JOURNAL (2008)
Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation
Judy Creighton et al.
JOURNAL OF CELL SCIENCE (2008)
The Penile Erection Efficacy of a New Phosphodiesterase Type 5 Inhibitor, Mirodenafil (SK3530), in Rabbits with Acute Spinal Cord Injury
Ji-Youn Jung et al.
JOURNAL OF VETERINARY MEDICAL SCIENCE (2008)
Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease
Zena DeMarch et al.
NEUROBIOLOGY OF DISEASE (2008)
Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia
Anelia Horvath et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet funcitons
Lindsay S. Wilson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia
Lingzhi Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PDE9A-MEDIATED REGULATION OF CGMP: IMPACT ON SYNAPTIC PLASTICITY
Frank Menniti et al.
SCHIZOPHRENIA RESEARCH (2008)
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
S. Hossein Fatemi et al.
SCHIZOPHRENIA RESEARCH (2008)
Functional Rescue of Degenerating Photoreceptors in Mice Homozygous for a Hypomorphic cGMP Phosphodiesterase 6 b Allele ( Pde6bH620Q)
Richard J. Davis et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)
Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil
Huanchen Wang et al.
MOLECULAR PHARMACOLOGY (2008)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
Huanchen Wang et al.
BIOCHEMICAL JOURNAL (2007)
Disrupted in schizophrenia 1 and phosphodiesterase 413: towards an understanding of psychiatric illness
J. Kirsty Millar et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3
James Surapisitchat et al.
CIRCULATION RESEARCH (2007)
PI3Kγ is required for PDE4, not PDE3, activity in subcellular Microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes
Benoit-Gilles Kerfant et al.
CIRCULATION RESEARCH (2007)
Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme
J. A. Siuciak et al.
NEUROPHARMACOLOGY (2007)
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway
Benjamin D. Sachs et al.
JOURNAL OF CELL BIOLOGY (2007)
Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB
Faiyaz Ahmad et al.
BIOCHEMICAL JOURNAL (2007)
Behavioral phenotypes of Disc1 missense mutations in mice
Steven J. Clapcote et al.
NEURON (2007)
cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system - A molecular toolbox for generating compartmentalized cAMP signaling
Miles D. Houslay et al.
CIRCULATION RESEARCH (2007)
Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation
Daniel Palmer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells
Eduard Stefan et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Re-discovering PDE3 inhibitors - New opportunities for a long neglected target
Philip E. Thompson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity
Hengming Ke et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
Inflammation and metabolic disorders
Goekhan S. Hotamisligil
NATURE (2006)
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
Ma-Li Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+
Elaine Huston et al.
JOURNAL OF CELL SCIENCE (2006)
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
Hossein A. Ghofrani et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Multiple conformations of phosphodiesterase-5 - Implications for enzyme function and drug development
Huanchen Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia
Anelia Horvath et al.
NATURE GENETICS (2006)
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes
Hongli Dong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C
Ping Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival
DJ Nagel et al.
CIRCULATION RESEARCH (2006)
Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase
Q Huai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Phosphodiesterase inhibitors in airways disease
KF Chung
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Compartmentalized phosphodiesterase-2 activity blunts β-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway
M Mongillo et al.
CIRCULATION RESEARCH (2006)
AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa
M Bajpai et al.
BIOLOGY OF REPRODUCTION (2006)
Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
Andrew T. Bender et al.
PHARMACOLOGICAL REVIEWS (2006)
Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium
R Hambleton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
JK Millar et al.
SCIENCE (2005)
Sildenafil citrate therapy for pulmonary arterial hypertension
N Galiè et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428
MP Rubio et al.
BIOCHEMICAL JOURNAL (2005)
Phosphodiesterase-4 as a therapeutic target
MD Houslay et al.
DRUG DISCOVERY TODAY (2005)
Coronary stent restenosis in patients treated with cilostazol
JS Douglas et al.
CIRCULATION (2005)
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias
SE Lehnart et al.
CELL (2005)
Dipyridamole, an underestimated vascular protective drug
W Schaper
CARDIOVASCULAR DRUGS AND THERAPY (2005)
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
KL Dodge-Kafka et al.
NATURE (2005)
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages
SLC Jin et al.
JOURNAL OF IMMUNOLOGY (2005)
3′,5′-Cyclic nucleotide phosphodiesterase 11A:: localization in human tissues
K Loughney et al.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2005)
The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases
DT Manallack et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors
S Minguet et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Leber congenital amaurosis linked to AIPL1: A mouse model reveals destabilization of cGMP phosphodiesterase
V Ramamurthy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IκB proteins
P Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation
M Ariga et al.
JOURNAL OF IMMUNOLOGY (2004)
A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases
KYJ Zhang et al.
MOLECULAR CELL (2004)
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7:: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes
SJ Smith et al.
MOLECULAR PHARMACOLOGY (2004)
Structural basis for the activity of drugs that inhibit phosphodiesterases
GL Card et al.
STRUCTURE (2004)
A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines
AL Asirvatham et al.
JOURNAL OF IMMUNOLOGY (2004)
Phosphodiesterase 7A-deficient mice have functional T cells
GC Yang et al.
JOURNAL OF IMMUNOLOGY (2003)
The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis
Q Huai et al.
BIOCHEMISTRY (2003)
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
S Gretarsdottir et al.
NATURE GENETICS (2003)
Immunohistochemical localization of PDE10A in the rat brain
TF Seeger et al.
BRAIN RESEARCH (2003)
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2
GB Bolger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
AWD 12-281 a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis
W Bäumer et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2003)
β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi
GS Baillie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Targeting of cyclic AMP degradation to β2-adrenergic receptors by β-arrestins
SJ Perry et al.
SCIENCE (2002)
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis
A Robichaud et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart
Y Shakur et al.
CARDIOVASCULAR DRUGS AND THERAPY (2002)
A phosphatidylinositol 3kinase-phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
AZ Zhao et al.
NATURE NEUROSCIENCE (2002)
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
SLC Jin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Myomegalin is a novel protein of the Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase
I Verde et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159
TY Oh et al.
ARCHIVES OF PHARMACAL RESEARCH (2000)
Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
G Hansen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A genetically encoded, fluorescent indicator for cyclic AMP in living cells
M Zaccolo et al.
NATURE CELL BIOLOGY (2000)