Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 12, Issue 6, Pages 465-483Publisher
NATURE RESEARCH
DOI: 10.1038/nrd4023
Keywords
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Funding
- AMC Postdoctoral fellowship
- ZonMw-VENI [91613050]
- Nestle Chair in Energy Metabolism
- Ecole polytechnique federale de Lausanne (EPFL)
- EU Ideas program [ERC-2008-AdG-231138]
- US National Institutes of Health [1R01HL 106511-01A1, R01AG043930]
- Velux Stiftung Research Grant Program
- Swiss National Science Foundation [31003A-124713, CRSII3-136201]
- Swiss National Science Foundation (SNF) [CRSII3_136201] Funding Source: Swiss National Science Foundation (SNF)
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Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous pathways maintain and/or restore proper mitochondrial function, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy and the mitochondrial unfolded protein response. New and powerful phenotypic assays in cell-based models as well as multicellular organisms have been developed to explore these different aspects of mitochondrial function. Modulating mitochondrial function has therefore emerged as an attractive therapeutic strategy for several diseases, which has spurred active drug discovery efforts in this area.
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