4.8 Review

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities

Related references

Note: Only part of the references are listed.
Article Oncology

Are KRAS/BRAF Mutations Potent Prognostic and/or Predictive Biomarkers in Colorectal Cancers?

Tomoya Yokota

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)

Review Pharmacology & Pharmacy

Translational approaches targeting the p53 pathway for anti-cancer therapy

Frank Essmann et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Oncology

The metastatic niche and stromal progression

Jonathan P. Sleeman

CANCER AND METASTASIS REVIEWS (2012)

Review Immunology

Current advances in humanized mouse models

Ryoji Ito et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2012)

Article Pharmacology & Pharmacy

Interleukin-6/interleukin-6 Receptor Pathway as a New Therapy Target in Epithelial Ovarian Cancer

Eveline M. Dijkgraaf et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Review Pharmacology & Pharmacy

Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy

Libero Santarpia et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

Article Multidisciplinary Sciences

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett et al.

NATURE (2012)

Article Multidisciplinary Sciences

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Ravid Straussman et al.

NATURE (2012)

Article Multidisciplinary Sciences

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Timothy R. Wilson et al.

NATURE (2012)

Review Biotechnology & Applied Microbiology

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu

Mallika Singh et al.

NATURE BIOTECHNOLOGY (2012)

Review Genetics & Heredity

Genomically humanized mice: technologies and promises

Anny Devoy et al.

NATURE REVIEWS GENETICS (2012)

Editorial Material Medicine, General & Internal

Challenges Facing JAK Inhibitor Therapy for Myeloproliferative Neoplasms

Ayalew Tefferi

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Paraneoplastic Thrombocytosis in Ovarian Cancer

Rebecca L. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Survival in BRAF V600-Mutant Advanced Melanoma Treated with Vemurafenib

Jeffrey A. Sosman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Multidisciplinary Sciences

Functional genomics identifies therapeutic targets for MYC-driven cancer

Masafumi Toyoshima et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

Lapatinib and Obatoclax Kill Tumor Cells through Blockade of ERBB1/3/4 and through Inhibition of BCL-xL and MCL-1

Nichola Cruickshanks et al.

MOLECULAR PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E. Delmore et al.

Review Biochemistry & Molecular Biology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

Scott Valastyan et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Cell Biology

Immune microenvironments in solid tumors: new targets for therapy

Stephen L. Shiao et al.

GENES & DEVELOPMENT (2011)

Article Medicine, Research & Experimental

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

Edward H. Flach et al.

MOLECULAR PHARMACEUTICS (2011)

Review Medicine, Research & Experimental

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

Jonathan W. Wojtkowiak et al.

MOLECULAR PHARMACEUTICS (2011)

Article Multidisciplinary Sciences

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikos I. Poulikakos et al.

NATURE (2011)

Editorial Material Biochemistry & Molecular Biology

Histamine restricts cancer: nothing to sneeze at

Brian Ruffell et al.

NATURE MEDICINE (2011)

Review Biochemistry & Molecular Biology

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Mina J. Bissell et al.

NATURE MEDICINE (2011)

Review Oncology

Immune parameters affecting the efficacy of chemotherapeutic regimens

Laurence Zitvogel et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Review Biochemical Research Methods

Antibodies in oncology

Vinochani Pillay et al.

NEW BIOTECHNOLOGY (2011)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Multidisciplinary Sciences

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

Jean-Pierre Gillet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Hiu Wing Cheung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

Triona Ni Chonghaile et al.

SCIENCE (2011)

Review Cell & Tissue Engineering

Biologic Characteristics of Bone Marrow Mesenchymal Stem Cells in Myelodysplastic Syndromes

Maria-Christina Kastrinaki et al.

CURRENT STEM CELL RESEARCH & THERAPY (2011)

Review Oncology

Anaplastic Thyroid Cancer: A Review of Epidemiology, Pathogenesis, and Treatment

Govardhanan Nagaiah et al.

JOURNAL OF ONCOLOGY (2011)

Review Oncology

Mouse models of advanced spontaneous metastasis for experimental therapeutics

Giulio Francia et al.

NATURE REVIEWS CANCER (2011)

Review Oncology

RAS oncogenes: weaving a tumorigenic web

Yuliya Pylayeva-Gupta et al.

NATURE REVIEWS CANCER (2011)

Review Oncology

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

David G. DeNardo et al.

CANCER AND METASTASIS REVIEWS (2010)

Article Oncology

Siltuximab, a Novel Anti-Interleukin-6 Monoclonal Antibody, for Castleman's Disease

Frits van Rhee et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Review Oncology

Cancer and Inflammation: Promise for Biologic Therapy

Sandra Demaria et al.

JOURNAL OF IMMUNOTHERAPY (2010)

Article Oncology

Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors

Ellen Weisberg et al.

MOLECULAR CANCER THERAPEUTICS (2010)

Article Multidisciplinary Sciences

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Cory M. Johannessen et al.

NATURE (2010)

Article Multidisciplinary Sciences

Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian et al.

NATURE (2010)

Article Multidisciplinary Sciences

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

Douglas W. McMillin et al.

NATURE MEDICINE (2010)

Article Medicine, General & Internal

Anaplastic Lymphoma Kinase Inhibition in Non-Small-Cell Lung Cancer

Eunice L. Kwak et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Medicine, General & Internal

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Multidisciplinary Sciences

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

Kenneth E. Hung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Hematology

Third-Generation Tyrosine Kinase Inhibitors and Beyond

Alfonso Quintas-Cardama et al.

SEMINARS IN HEMATOLOGY (2010)

Review Oncology

Examining the Metastatic Niche: Targeting the Microenvironment

Theresa Guise

SEMINARS IN ONCOLOGY (2010)

Review Oncology

Does tumour dormancy offer a therapeutic target?

Paul E. Goss et al.

NATURE REVIEWS CANCER (2010)

Review Immunology

T Cell Activation

Jennifer E. Smith-Garvin et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Article Hematology

In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465

Joseph M. Negri et al.

BRITISH JOURNAL OF HAEMATOLOGY (2009)

Article Oncology

Osteosclerotic prostate cancer metastasis to murine bone are enhanced with increased bone formation

Ronald R. Gomes et al.

CLINICAL & EXPERIMENTAL METASTASIS (2009)

Review Biochemistry & Molecular Biology

Revisiting the seed and soil in cancer metastasis

Martin Mendoza et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Hematology

Integrins - The keys to unlocking angiogenesis

Rita Silva et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

Editorial Material Pharmacology & Pharmacy

The state of innovation in drug development

I. Kola

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

Review Medicine, Research & Experimental

The anticancer immune response: indispensable for therapeutic success?

Laurence Zitvogel et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Review Biotechnology & Applied Microbiology

Protein therapeutics: A summary and pharmacological classification

Benjamin Leader et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Article Multidisciplinary Sciences

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

Nancy Dumont et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Antoine E. Karnoub et al.

NATURE (2007)

Review Immunology

Humanized mice in translational biomedical research

Leonard D. Shultz et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Review Oncology

Economics of new oncology drug development

Joseph A. DiMasi et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Review Biochemistry & Molecular Biology

Cancer metastasis:: Building a framework

Gaorav P. Gupta et al.

Review Biochemistry & Molecular Biology

Mutations in the NF-κB signaling pathway:: implications for human disease

G. Courtois et al.

ONCOGENE (2006)

Review Biochemistry & Molecular Biology

Tumor metastasis: mechanistic insights and clinical challenges

Patricia S. Steeg

NATURE MEDICINE (2006)

Article Genetics & Heredity

Distinct epigenetic changes in the stromal cells of breast cancers

M Hu et al.

NATURE GENETICS (2005)

Article Oncology

A mouse mode of human breast cancer metastasis to human bone

C Kuperwasser et al.

CANCER RESEARCH (2005)

Article Medicine, General & Internal

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

PG Richardson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Review Developmental Biology

Implantation mechanisms: insights from the sheep

TE Spencer et al.

REPRODUCTION (2004)

Article Multidisciplinary Sciences

Stromal fibroblasts in cancer initiation and progression

NA Bhowmick et al.

NATURE (2004)

Review Multidisciplinary Sciences

Inflammation and cancer

LM Coussens et al.

NATURE (2002)

Review Oncology

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

T Hideshima et al.

NATURE REVIEWS CANCER (2002)

Review Oncology

Putting tumours in context

MJ Bissell et al.

NATURE REVIEWS CANCER (2001)