Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 10, Issue 7, Pages 521-535Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3499
Keywords
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Funding
- US National Science Foundation (University of Pennsylvania's Materials Research Science and Engineering Center and Nano/Bio Interface Center)
- US National Institutes of Health (National Institute of Biomedical Imaging and Bioengineering and National Heart, Lung and Blood Institute)
- US National Institutes of Health [CA140476]
- US Department of Defense
- University of California
- National Research Foundation of Korea [핵C6A3404] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations. Natural particulates-that range from pathogens to mammalian cells-are therefore worth examining in more depth, as they are highly optimized for their specific functions in vivo and possess features that are often desired in drug delivery carriers. With a better understanding of these biological systems, in conjunction with the availability of advanced biotechnology tools that are useful for re-engineering the various natural systems, researchers have started to exploit natural particulates for multiple applications in the delivery of proteins, small interfering RNA and other therapeutic agents. Here, we review the natural drug delivery carriers that have provided the basis and inspiration for new drug delivery systems.
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