Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 10, Issue 1, Pages 29-46Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3321
Keywords
-
Funding
- Parkinson&apos
- s UK [G-4055, F-0702] Funding Source: Medline
- Alzheimers Research UK [ART-PG2001-1, ART-RF2004B-1] Funding Source: researchfish
- Parkinson"
- s UK [F-0702] Funding Source: researchfish
Ask authors/readers for more resources
The ubiquitin-proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways are integral to cellular protein homeostasis. The growing recognition of the fundamental importance of these pathways to normal cell function and in disease has prompted an in-depth search for small-molecule inhibitors that selectively block the function of these pathways. However, our limited understanding of the molecular mechanisms and biological consequences of UBL conjugation is a significant hurdle to identifying drug-like inhibitors of enzyme targets within these pathways. Here, we highlight recent advances in understanding the role of some of these enzymes and how these new insights may be the key to developing novel therapeutics for diseases including immuno-inflammatory disorders, cancer, infectious diseases, cardiovascular disease and neurodegenerative disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available