Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 9, Issue 4, Pages 308-324Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd3012
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Neutralizing Antibody Consortium of the International AIDS Vaccine Initiative
- National Institute of Allergy and Infectious Diseases
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Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes.
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