Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 7, Issue 5, Pages 391-397Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2541
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To fully exploit the potential of kinases as drug targets, novel strategies for the efficient discovery of inhibitors are required. In contrast to the traditional, linear process of inhibitor discovery, high-throughput kinase profiling enables a parallel approach by interrogating compounds against hundreds of targets in a single screen. Compound potency and selectivity are determined simultaneously, providing a choice of targets to pursue that is guided by the quality of lead compounds available, rather than by target biology alone.
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