Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 7, Issue 9, Pages 759-770Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2638
Keywords
-
Funding
- National Institutes of Health (NIH) [R01GM66189]
- Intramural Research Program of NIH
- National Institute on Alcohol Abuse and Alcoholism
Ask authors/readers for more resources
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A(1), A(2A), A(2B) and A(3). Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available