Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 7, Issue 9, Pages 738-745Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2606
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Funding
- NMR-Life Coordination Action [LSHG-CT-2005-018, 758]
- MCYT-FEDER [Bio2005-00295]
- Ente CR Firenze
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0741914] Funding Source: National Science Foundation
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In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. in this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.
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