Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 7, Issue 3, Pages 241-254Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd2444
Keywords
-
Ask authors/readers for more resources
The concept of the gut forming the centre of an integrated gut-brain-energy axis-modulating appetite, metabolism and digestion-opens up new paradigms for drugs that can tackle multiple symptoms in complex upper gastrointestinal disorders. These include eating disorders, nausea and vomiting, gastroesophageal reflux disease, gastroparesis, dyspepsia and irritable bowel syndrome. The hormones that modulate gastric motility represent targets for gastric prokinetic drugs, and peptides that modify eating behaviours may be targeted to develop drugs that reduce nausea, a currently poorly treated condition. The gut-brain axis may therefore provide a range of therapeutic opportunities that deliver a more holistic treatment of upper gastrointestinal disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available