Journal
NATURE REVIEWS CLINICAL ONCOLOGY
Volume 15, Issue 11, Pages 657-658Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41571-018-0077-0
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Funding
- US NIH National Cancer Institute [2P01CA163205, CA069246-20, P50CA165962]
- US National Institute of Neurological Disorders and Stroke [5K08NS101091]
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A recent clinical trial of a virotherapy approach, consisting of an engineered poliovirus, has provided evidence of apparently durable responses in patients with recurrent glioblastoma. The results of this trial and others indicate that virotherapy might be an effective tool in anticancer immunotherapy. Yet, caution must be exercised until appropriately powered randomized clinical trials truly show efficacy.
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