4.6 Editorial Material

HAEMATOLOGICAL CANCER Idelalisib-targeting PI3Kδ in patients with B-cell malignancies

Journal

NATURE REVIEWS CLINICAL ONCOLOGY
Volume 11, Issue 4, Pages 184-186

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2014.42

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Funding

  1. Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0409] Funding Source: researchfish
  2. Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0409] Funding Source: Medline
  3. NCI NIH HHS [P30 CA016672] Funding Source: Medline
  4. Wellcome Trust [095691] Funding Source: Medline
  5. BBSRC [BBS/E/B/000C0409] Funding Source: UKRI

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Idelalisib, the first PI3K delta inhibitor in clinical use, has excellent activity in patients with chronic lymphocytic leukaemia and indolent B-cell lymphomas, heralding a new era of targeted therapy for these types of cancer. Idelalisib intercepts critical communications between B cells and the microenvironment, including B-cell receptor signalling and chemokine

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